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Model of NB cell apoptosis induction under normal and low serum conditions. N-Myc induces proliferation in normal serum and apoptosis through caspase-9 (Casp9) in low serum. Mxi1-0 and Mxi1 block these N-Myc–induced effects. In the absence of amplified MYCN, Mxi1-0 and Mxi1 induce apoptosis through caspase-8 (Casp8), regardless of serum concentration.
