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. Author manuscript; available in PMC: 2015 Sep 11.
Published in final edited form as: Cell Rep. 2014 Aug 28;8(5):1354–1364. doi: 10.1016/j.celrep.2014.07.030

Figure 3. Unique changes in the insulin sequence of hystricognath rodents.

Figure 3

(A) Preproinsulin contains an amino-terminal signal peptide (SP) and is processed to yield two insulin peptide chains (α and β), as well as connecting peptide (C-peptide). The sequence of the β-chain is shown in orange. Residues that are uniquely altered in hystricognath rodents are highlighted in red. (B) Heatmap showing the expression (log2 fold-change) of IGF2 mRNA in the liver. (C) Schematic model, which applies to African mole rats and other hystricognaths, wherein IGF2 (normally only expressed in the fetus) signals via the insulin receptor and partly compensates for altered insulin sequence. See also Figure S2.