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. 2015 Mar 5;10(3):e0118466. doi: 10.1371/journal.pone.0118466

Fig 2. Interaction between ancestry and vitamin D in the Meth7 co-methylation network.

Fig 2

Meth7 is a co-methylation network that is influenced by both ancestry (based on self-reported race by mothers) and levels of maternal vitamin D. These are regression plots for the Meth5 module eigengene, and the top two hub genes in Meth5: MRPS34 and NEO1. Average methylation of the CpG network is higher in African Americans (AAs). Negative correlation between vitamin D (ng/ml) and methylation levels (M-value) is seen only in European Americans (EAs; for EAs, R = -0.35, p-value = 0.004 for Meth7 and vitamin D; R = -0.28, p-value = 0.025 for MRPS34 and vitamin D; and R = -0.46, p-value < 0.0001 for NEO1 and vitamin D).