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. 2015 Mar 5;10(3):e0118787. doi: 10.1371/journal.pone.0118787

Fig 2. Spontaneous withdrawal from a chronic METH infusion elevates ICSS thresholds: reversal by acute METH.

Fig 2

ICSS thresholds (A) and response latencies (B) (expressed as percent of baseline, mean ± SEM) during (“pump in” phase) and after (“pump out” phase) chronic exposure to saline or METH (10 mg/kg/day) in Experiment 1b. Rats were administered s.c. SAL or METH 0.3 mg/kg prior to the first session of the pump out phase. *, ** Significantly different from SAL+ SAL at that session, p < 0.05 or 0.01. # METH + METH significantly different from METH + SAL at that session, p < 0.01. For clarity, significant differences in marginal means between the METH + SAL and METH + METH groups compared to the SAL + SAL group during the pump in phase are not shown in Fig. 2A (see text for further details).