Table 1.
Medians, maximum, and minimum values of parameters related to liver function of nondiabetic control and untreated diabetic rats during the various experimental follow-up periods.
| Groups | Follow-up | Parameters | ||||
|---|---|---|---|---|---|---|
| Bilirubin | AST | ALT | Alkaline Ph | γ-GT | ||
| (mg/dL) | (U/L) | (U/L) | (U/L) | (U/L) | ||
| NC | 2 weeks | 0.42 (0.32–0.76) | 30 (20–32) | 36 (34–50) | 68 (60–105) | 84 (52–96) |
| UD | 0.56 (0.38–0.80) | 96* (35–115) | 87* (42–108) | 76 (66–102) | 70 (58–105) | |
|
| ||||||
| P value | 0.6870 | <0.001 | <0.001 | 0.3860 | 0.4254 | |
|
| ||||||
| NC | 6 weeks | 0.50 (0.30–0.80) | 26.5 (18–36) | 41.0 (35–52) | 79.5 (65–102) | 70.5 (46–112) |
| UD | 0.54 (0.38–0.75) | 29.0 (18–36) | 92.0* (37–96) | 85.0 (67–110) | 80.5 (56–108) | |
|
| ||||||
| P value | 0.9705 | 0.6305 | <0.001 | 0.4813 | 0.3930 | |
|
| ||||||
| NC | 14 weeks | 0.60 (0.55–0.74) | 26.5 (22–30) | 39.0 (28–50) | 55.0 (48–72) | 31.0 (22–45) |
| UD | 0.70 (0.56–0.80) | 28.5 (26–32) | 80.0* (66–97) | 64.5 (50–80) | 39.0 (32–50) | |
|
| ||||||
| P value | 0.3429 | 0.3229 | <0.001 | 0.3362 | 0.2702 | |
|
| ||||||
| NC | 26 weeks | 0.39 (0.28–0.52) | 42.0 (38–50) | 43.0 (26–55) | 55.0 (36–80) | 40.5 (22–54) |
| UD | 0.44 (0.30–0.60) | 51.5 (40–56) | 78.5* (72–92) | 67.5 (55–90) | 53.0 (38–70) | |
|
| ||||||
| P value | 0.4857 | 0.2000 | <0.001 | 0.3429 | 0.2000 | |
NC: nondiabetic control; UD: untreated diabetic; AST: aspartate aminotransferase; ALT: alanine aminotransferase; Alkaline Ph: alkaline phosphatase; γ-GT: gamma glutamil transferase.
*NC < UD at 2, 6, 14, and 26 weeks of follow-up (Mann-Whitney test).