Table 1. Firing rates of GP, STN and SNr neurons before and after dopamine or quinpirole injection into the GP.
FR increase cells | FR decrease cells | Non responsive cells | ||||
---|---|---|---|---|---|---|
Before | After | Before | After | Before | After | |
GP neurons | ||||||
Dopamine | 18.64±1.62 | 27.03±2.44*** | 21.15±8.95 | 15.20±9.43* | 22.63±2.07 | 22.63±2.12ns |
Quinpirole | 14.31±2.14 | 19.44±2.72** | 20.22±3.31 | 10.87±1.56** | 24.68±3.96 | 25.61±3.99ns |
STN neurons | ||||||
Dopamine | 4.72±0.60 | 6.66±0.96* | 5.12±0.79 | 3.43±0.56* | 6.39±0.72 | 6.22±0.60ns |
Quinpirole | 11.92±6.69 | 18.86±4.10* | 11.36±2.51 | 7.23±1.43* | 12.91±2.48 | 13.33±2.67ns |
SNr neurons | ||||||
Dopamine | 9.03±2.90 | 13.10±3.78* | 9.41±1.24 | 5.73±1.03* | 12.30±4.16 | 12.54±4.64ns |
Quinpirole | 21.82±6.00 | 32.12±7.40* | 16.10±2.11 | 8.99±1.60* | 12.91±2.48 | 13.33±2.67ns |
FR: firing rate in spikes/sec; values are presented as the mean ± SEM. Statistical analysis using paired t-test was performed;
*: p<0.05,
**: p<0.01,
***: p<0.001 in comparison with before drug injection.