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. 2015 Mar 5;10(3):e0118712. doi: 10.1371/journal.pone.0118712

Fig 4. Comparison of effects of small molecule inhibitors of specific Gβγ-regulated downstream signaling proteins on PDE activity in asthmatic vs. normal HASM cells.

Fig 4

Relative to baseline in normal HASM cells, constitutively heightened baseline PDE activity in asthmatic HASM cells is suppressed to near normal levels at 2 hr following treatment with either the c-Src inhibitor, SU6656, or the MEK-ERK1/2 inhibitor, U0126, whereas treatment with inhibitors of either p38 MAPK (SB202190), PI3K (LY294002), or PKA (H89) had no significant effect. Note: neither inhibitor had an appreciable effect on PDE activity in normal HASM cells. Data are mean ± SE values, each based on 3–6 determinations. Comparisons between asthmatic vs. normal HASM cells are made using two-tailed Student t-test. *p<0.05; **p<0.01.