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. 2015 Mar 5;10(3):e0118845. doi: 10.1371/journal.pone.0118845

Fig 6. Effect of NNK, atenolol, and ICI118551 on the tumorigenicity of ESCC cells in vivo.

Fig 6

KYSE410 cells were subcutaneously injected into the right posterior flank of nude mice. At 1 week post-implantation, the mice were randomized into six groups with six animals in each group to receive various treatments: DMSO, atenolol (10 mg/kg/day), ICI118551 (10 mg/kg/day), NNK (1.2 mg/kg/day), atenolol+NNK, and ICI118551+NNK. A, Representative images of the subcutaneous tumors formed in nude mice. B, Histograms showing the average tumor volume ± SD per group. C, VEGF expression in tumors. D, Histological scores of VEGF expression in each group. E, CD31 expression in tumors. F, Microvessel density (MVD) of each group. Data are the means ± SD. ε p<0.05 compared with the blank group; ξ p<0.05 compared with the NNK group.