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. 2015 Mar 5;11(3):e1004703. doi: 10.1371/journal.ppat.1004703

Fig 8. Interdependence of PV propagation and activation of the PDK/PKC/PKB signaling cascade.

Fig 8

Schematic representation of parvoviral interaction with the PDK1/PKC/PKB signaling cascade in permissive host and human cancer cells (left panel) versus non-permissive normal human cells (right panel). In permissive cells (e.g. tumor cells) PDK1-S135 phosphorylation stimulates parvovirus propagation and prolongs survival independently of growth factor signaling. In non-permissive normal human cells, due the failure of PVs to induce PDK1 stimulation, NS1 remains inactive.