Table 3.

Baseline Demographic/Injury Data

Variable	Control ’00-06 N=14 ± SEM	Control ’06-08 N=5 ± SEM	p-value (’00-06 vs ’06-08)	Control ’00-08 N=19 ± SEM	Phase I N=10 ± SEM	p-value (Control ’06-‘08 vs Phase I)	p-value (Control ’00-‘08 vs Phase I)
Males %	64% (n=9)	40% (n=2)	0.6	60% (n=11)	70% (n=7)	0.3	0.7
Mean Age	8.935 ± 0.7	8.6 ± 1.6	0.8	8.8 ± 0.8	8.9 ± 0.9	0.9	1.0
Injury Severity Score (ISS)	29 ± 1.1	35.0 ± 6.6	0.03	30 ± 1.5	30 ± 1.9	0.2	0.3
Best initial GCS	6.3 ± 0.3	6.6 ± 1.1	0.7	6.4 ± 0.4	5.8 ± 0.4	0.3	0.3
Modified Marshall Score	3.7 ± 0.3	3.3 ± 1.7	0.6	3.6 ± 0.3	3.7 ± 0.5	0.7	0.8
Opening* Pressure	20 ± 2.7 (n=12)	22 ±4.3 (n=5)	0.7	22 ± 2.4 (n=17)	21 ± 2.1 (n=10)	0.6	0.7
Craniectomies	29% (n=4)	20% (n=1)	0.1	26% (n=5)	50% (n=10)	0.1	0.4
EVD	42% (n=5)	0%	0.2	29% (n=5)	40% (n=4)	0.1	0.5

^*2 patients in the 2000-2006 control group did not have ICP monitor placed