Table 2.

Multivariate Analysis

Factor	Level	n	Hazard Ratio	95% Hazard Ratio Confidence Limits		P-value
Overall Mortality^		897
Regimen	No-TBI	515	1
	TBI	382	1.09	0.91	1.32	0.35
Age	40 – 49	217	1			<0.001*
	50 – 59	406	1.31	1.03	1.66	0.03
	≥ 60	274	1.66	1.28	2.15	<0.001
KPS	90 – 100	570	1			<0.001*
	< 90	234	1.49	1.21	1.83	<0.001
	Unknown	93	1.42	1.07	1.90	0.016
Donor type	HLA-identical sibling	374	1			<0.001*
	8/8 matched unrelated donors	417	1.28	1.04	1.58	0.021
	7/8 matched unrelated donors	106	1.94	1.46	2.59	<0.001
Treated-related mortality$		897
Regimen	No-TBI	515	1
	TBI	382	1.10	0.85	1.41	0.48
Age	40 – 49	217	1			0.012*
	50 – 59	406	1.11	0.80	1.55	0.54
	≥ 60	274	1.59	1.12	2.24	0.009
Donor type	HLA-identical sibling	374	1			<0.001*
	8/8 matched unrelated donors	417	1.42	1.06	1.92	0.021
	7/8 matched unrelated donors	106	2.63	1.79	3.87	<0.001
Progression/Relapse%		897
Regimen	No-TBI	515	1
	TBI	382	1.05	0.83	1.33	0.68*
KPS	90 – 100	570	1			0.011
	< 90	234	1.42	1.10	1.83	0.007
	Unknown	93	1.40	0.99	1.98	0.05
In vivo T-cell depletion	No use of in-vivo T-cell depletion	628	1
	In-vivo T-cell depletion used	269	1.55	1.22	1.97	<0.001
Treatment failure&		897
Regimen	No-TBI	515	1
	TBI	382	0.97	0.81	1.15	0.70
KPS	90 – 100	570	1			0.005*
	< 90	234	1.34	1.10	1.62	0.003
	Missing	93	1.33	1.01	1.75	0.04
Donor type	HLA-identical sibling	374	1			<0.001*
	8/8 matched unrelated donors	417	1.21	1.00	1.47	0.05
	7/8 matched unrelated donors	106	1.79	1.36	2.34	<0.001
Acute GVHD Grade II–IV^^		896
Regimen	No-TBI	515	1
	TBI	382	1.54	1.19	2.00	0.001
KPS	90 – 100	570	1			0.016*
	< 90	234	1.45	1.09	1.92	0.010
	Missing	93	1.50	0.97	2.33	0.07
Sensitivity	Sensitive	492	1			<0.001*
	Resistant	129	2.01	1.35	2.99	<0.001
	Untreated/unknown/CLL	276	1.93	1.47	2.55	<0.001
History of prior autologous transplant	Previously received autologous transplant	167	1
	No history of prior autologous transplant	730	12.11	4.95	29.63	<0.001
Chronic GVHD$$		896
Regimen	No-TBI	514	1
	TBI	382	1.32	1.10	1.59	0.003
Donor type	HLA-identical sibling	373	1			0.003*
	8/8 matched unrelated donors	417	1.39	1.13	1.71	0.002
	7/8 matched unrelated donors	106	1.50	1.08	2.08	0.015
In vivo T-cell depletion	No use of in-vivo T-cell depletion	627	1
	In-vivo T-cell depletion used	269	0.60	0.47	0.75	<0.001

^*overall p-value

^{^}Model stratified by year of transplant and sensitivity. Other pair-wise contrasts: age (p-value= 0.024), donor type (p-value= 0.002)

^$Model stratified by year of transplant and sensitivity. Other pair-wise contrasts: age (p-value= 0.015), donor type (p-value <0.001)

^%Model stratified by disease group and sensitivity.

^&Model stratified by disease group, year of transplant, and sensitivity. Other pair-wise contrasts: donor type (p-value= 0.003)

^{^^}Other pair-wise contrasts: sensitivity (p-value= 0.84)

^$$Other pair-wise contrasts: donor type (p-value= 0.62)