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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Apoptosis. 2015 Apr;20(4):551–561. doi: 10.1007/s10495-015-1105-5

FIG. 3. Effect of HN and HNG-F6A on Cyclophosphamide (CP)-induced male germ cell apoptosis.

FIG. 3

Mice were treated with vehicle (Control), HN, HNG-F6A (Humanin-S14G-F6A), CP, CP+HN or CP+HNG-F6A as described in experimental procedures (n=4 each group). HN or HNG-F6A alone did not change apoptosis compared with control. Compared with control, CP increased germ cell apoptosis both in early+late (I–IV and XI–XII) and middle (VII–VIII) stages. HN significantly suppressed CP-induced apoptosis in early+late stages but not in middle stages. HNG-F6A prevented CP-induce apoptosis both in early+late and middle stages remarkably. Values are means ± SEM. Means with unlike superscripts are significantly (P<0.05) different.