Table 2.
Clinical outcomes by BMI category.
| UW | NW | OW | OB | |
|---|---|---|---|---|
| Count (%) or Median (range, IQR) | ||||
| Total | 20 | 290 (34.5) | 287 (32.0) | 301 (33.5) |
| Follow-up time (months) | 29.4 (0.8-113.7, 7.6-64.4) | 18.9 (0.5-117.7, 5.7-50.0) | 17.8 (0.3-117.6, 5.4-49.9) | 17.8 (0.6-115.5, 5.9-43.4) |
| Hospital length of stay (days) | 29 (18-68, 24-35) | 24 (12-175, 21-29) | 23 (0-154, 20-27) | 23 (0-98, 21-26) |
| Acute GVHD* | ||||
| Yes | 9 (1.0) | 159 (17.7) | 174 (19.4) | 178 (19.8) |
| 1 | – | 42 (4.7) | 50 (5.6) | 36 (4.0) |
| 2 | 4 (0.4) | 69 (7.7) | 64 (7.1) | 76 (8.5) |
| 3 | 4 (0.4) | 24 (2.7) | 25 (2.8) | 32 (3.6) |
| 4 | 1 (0.1) | 24 (2.7) | 35 (3.9) | 34 (3.8) |
| No | 11 (1.2) | 131 (14.6) | 113 (12.6) | 123 (13.7) |
| Chronic GVHD | ||||
| Yes | 9 (1.0) | 135 (15.0) | 148 (16.5) | 166 (18.5) |
| No | 11 (1.2) | 155 (17.3) | 139 (15.5) | 135 (15.0) |
| Relapse | ||||
| Yes | 6 (0.7) | 116 (12.9) | 107 (11.9) | 91 (10.1) |
| No | 14 (1.6) | 174 (19.4) | 180 (20.0) | 210 (23.4) |
| Survival | ||||
| Alive | 10 (1.1) | 133 (14.8) | 122 (13.6) | 116 (12.9) |
| Dead | 10 (1.1) | 157 (17.5) | 165 (18.4) | 185 (20.6) |
| Causes of Death | ||||
| Relapse | 4 (40.0) | 99 (63.1) | 91 (55.2) | 76 (41.1) |
| Acute GVHD | 2 (20.0) | 26 (16.6) | 36 (21.8) | 35 (18.9) |
| Chronic GVHD | 2 (20.0) | 20 (12.7) | 27 (16.4) | 57 (30.1) |
| Graft rejection or failure | – | 2 (1.3) | 3 (1.8) | 2 (1.1) |
| Idiopathic pneumonia syndrome | – | – | 1 (0.6) | 7 (3.8) |
| Infection† | 1 (10.0) | 2 (1.3) | 3 (1.8) | 2 (1.1) |
| Hepatic veno-occlusive disorder | – | 1 (0.6) | 1 (0.6) | 3 (1.6) |
| Engraftment syndrome | – | – | 1 (0.6) | 1 (0.5) |
| Cardiac event | – | 1 (0.6) | 1 (0.6) | – |
| PTLD | – | 1 (0.6) | – | – |
| Pulmonary hypertension | – | 1 (0.6) | – | – |
| Small bowel obstruction | – | – | – | 1 (0.5) |
| Accidental trauma | – | – | – | 1 (0.5) |
| Other‡ or unknown | 1 (10.0) | 4 (2.5) | 1 (0.6) | – |
*
Acute GVHD onset day ≤100 post-transplant and not post-relapse, max grade shown.
†
Among deaths from infection, one UW patient died from Pneumocystis jirovecii pneumonia, one NW patient from human herpes virus 6 meningoencephalitis, one NW, two OW and one OB patients from culture-negative sepsis, one OW patient from pneumonia of unknown etiology, and one OB patient from a bacterial infection at another hospital.
‡
One UW patient died from esophageal cancer; three NW patients died from lung cancer.
PTLD - post-transplant lymphoproliferative disorder.