Table 3.
Clinicopathological features and expression of mucin core proteins and CD10
|
MUC5AC |
MUC6 |
MUC2 |
CD10 |
|||||
| Positive (n = 12) | Negative (n = 35) | Positive (n = 4) | Negative (n = 43) | Positive (n = 20) | Negative (n = 27) | Positive (n = 7) | Negative (n = 40) | |
| Age (yr) | ||||||||
| Mean ± SD | 63.4 ± 15.11 | 58.8 ± 16.5 | 76.3 ± 10.01 | 58.7 ± 15.9 | 62.3 ± 15.3 | 58.0 ± 16.71 | 60.1 ± 15.1 | 59.8 ± 16.51 |
| (range) | (35-85) | (23-87) | (67-87) | (23-85) | (38-87) | (23-81) | (38-87) | (23-85) |
| Gender (male/female) | 10/2 | 19/16 | 3/1 | 26/17 | 9/11 | 18/9 | 3/4 | 27/14 |
| Gross appearance | ||||||||
| (polypoid/ulcerated) | 3/9 | 9/26 | 2/2 | 10/33 | 6/14 | 6/21 | 4/3a | 8/32a |
| Size (cm) | 5.3 ± 2.2 | 5.1 ± 1.9 | 5.0 ± 1.8 | 5.1 ± 2.0 | 5.7 ± 1.6a | 4.7 ± 2.2a | 5.9 ± 1.4a | 5.0 ± 2.1a |
| Location | ||||||||
| (duodenum/jejunum/ileum) | 2/5/5 | 12/16/7 | 2/1/1 | 12/20/11 | 6/11/3 | 8/10/9 | 4/2/1 | 10/19/11 |
| Histological subtype | ||||||||
| (tubular2/poorly/mucinous) | 6/3/3 | 27/6/2 | 3/0/1 | 30/9/4 | 13/2/5 | 10/7/0 | 7/0/0 | 29/9/5 |
| Invasion depth3 | ||||||||
| T1 | 0 | 2 | 0 | 2 | 2 | 0 | 2a | 0a |
| T2 | 2 | 2 | 2 | 2 | 2 | 2 | 2a | 2a |
| T3 | 2 | 16 | 0 | 18 | 6 | 12 | 1a | 17a |
| T4 | 8 | 15 | 2 | 21 | 10 | 13 | 2a | 21a |
| Lymphatic permeation n (%) | 10 (83) | 23 (66) | 2 (50) | 31 (72) | 12 (60) | 21 (78) | 3 (43) | 30 (75) |
| Venous invasion n (%) | 3 (25) | 9 (26) | 1 (25) | 11 (26) | 5 (25) | 7 (26) | 2 (29) | 10 (25) |
| Adenomatous component n (%) | 0 (0) | 3 (9) | 1 (25) | 2 (5) | 3 (15)a | 0 (0)a | 2 (29)a | 1 (3)a |
1
Age of one patient was unknown;
2
"tubular" contains well or moderately differentiated adenocarcinoma;
3
UICC TNM classification is used.
a
P < 0.05 vs positive group and negative group in the same mucin core protein or CD10. In comparison invasion depth, T1 vs T2-T4).