Table 5.
Clinicopathological features, microsatellite instability status and KRAS mutation
|
MSI |
KRAS |
|||
| MSI-H (n = 4) | MSI-L/MSS (n = 30) | Mutational type (n = 4) | Wild type (n = 33) | |
| Age (yr) | 69.5 ± 12.3 | 59.6 ± 15.91 | 53.3 ± 13.2 | 60.8 ± 16.21 |
| Gender (male/female) | 4/0 | 16/14 | 1/3 | 22/11 |
| Gross appearance (polypoid/ulcerated) | 1/3 | 6/24 | 2/2 | 9/24 |
| Size (cm) | 7.7 ± 1.1a | 5.1 ± 2.0a | 4.4 ± 1.0 | 5.5 ± 2.0 |
| Location (duodenum/jejunum/ileum) | 0/2/2 | 7/15/8 | 1/2/1 | 9/15/9 |
| Histological subtype (tubular2/poorly/mucinous) | 2/0/2 | 22/6/2 | 4/0/0 | 22/8/3 |
| Invasion depth3 | ||||
| T1 | 0 | 1 | 0 | 1 |
| T2 | 0 | 2 | 0 | 3 |
| T3 | 2 | 13 | 1 | 13 |
| T4 | 2 | 14 | 3 | 15 |
| Lymphatic permeation n (%) | 3 (75) | 23 (77) | 4 (100) | 22 (67) |
| Venous invasion n (%) | 1 (25) | 9 (30) | 1 (25) | 10 (30) |
| Adenomatous component n (%) | 0 (0) | 1 (3) | 0 (0) | 2 (6) |
1
Age of one patient was unknown;
2
"Tubular" contains well or moderately differentiated adenocarcinoma;
3
UICC TNM classification is used.
a
P < 0.05 vs control.