Table 1.
Patients' Demographics and the Identified Genes with Somatic Non-Synonymous Mutations for the TGCT Series Analyzed by Exome Sequencing
| Patient ID | Tumor ID | Age at Diagnosis of TGCT (Years) | Histology | Amount of Tumor Tissue in Samples (%) | Number of SBS | Number of Non-Synonymous SBS | Number of Indels | Number of Non-Synonymous Indels | Total Number of Non-Synonymous Mutations | Non-Synonymously Mutated Genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | I | 31 | Sem⁎ | 85 | 37 | 5 | 0 | 0 | 5 | ANK2, ANKRD36, CD40LG, PTPRA, ZNF569 |
| II | 33 | Sem⁎ | 90 | 42 | 11 | 1 | 0 | 11 | BMP1, CSPG5, CIITA, GPN1, LEF1, LZTS2, MAP1LC3C, NOL6, PDE10A, TNR, TUBGCP6 | |
| 2† | I | 30 | Sem⁎ | NA | 24 | 7 | 9 | 7 | 14 | DNAAF1, JMY, LIPA, PCDHB9, PDXDC1, PKD1L3, POLR2B, SRD5A3, TBC1D16, TCF25, VSIG1, WDR66, ZNF253, ZNF43, |
| II | 40 | Sem⁎ | NA | 53 | 20 | 2 | 1 | 21 | ABCC1, ARFGEF2, BIRC6, CCT2, MED10, NEB, PBX4, PDGFRA, PDGFRA, PTMA, PVRL3, RANBP9, RGS6, SUPT6H, TMEM87B, TSEN2, TTN, TYR,USP34, WHSC1, ZCCHC11 | |
| 3 | II | 38 | Nsem‡ | 50 | 37 | 9 | 1 | 0 | 9 | CDC27, CDC27, FAM120A, FAM135B, FILIP1, GOLGB1, NOS3, PHF19, XIRP2 |
| 4§ | I | 30 | Sem⁎ | 80¶ | 26 | 5 | 0 | 0 | 5 | ATG2B, MYO5A, OR10A4, WDR91, ZNF157 |
| II | 30 | Nsem‡ | 40 | 31 | 5 | 3 | 1 | 6 | CACNA1B, MDN1, REV1, SCAND3, UNG, XAF1 | |
| 5 | II | 26 | Nsem‡ | 30 | 47 | 16 | 0 | 0 | 16 | BSDC1, BUD13, CETP, COPRS, DCHS1, DNAJC28, KIDINS220, KL, NOL8, OSBPL5, PCDH10, PTMA, SEC23B, SUPT6H, TMEM237, UBR5 |
Abbreviations: Sem, seminoma; NSem, non-seminoma; NA, not available.
⁎
Pure seminoma.
†
Familial aggregation of TGCT.
‡
Non-seminoma independent of seminoma components.
§
Bilateral synchronous TGCT.
¶
50% lymphocytes in tumor tissue.