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. 2015 Mar 4;17(2):155–166. doi: 10.1016/j.neo.2014.12.003

Figure 5.

Figure 5

Subthreshold inhibition of NHE1 by cariporide synergistically potentiates erlotinib-dependent inhibition of 3D growth and invadopodia.

All experiments were conducted in PANC-1 cells in the absence or presence of 100 ng/ml EGF with 1 μM cariporide and in increasing erlotinib concentrations.

(A) 3D Matrigel growth as in Figure 2. Mean ± SEM, unpaired Student’s t test. *P < .05, **P < .01, and ****P < .0001 compared with the control cells and †P < .01, ††P < .001, and †††P < .0001 compared with the respective EGF cells for each line.

(B) Invadopodia activity measured as in Figure 3. Mean ± SEM, unpaired Student’s t test. **P < .01 and ***P < .001 compared with the control cells and †P < .01, ††P < .001, and †††P < .0001 compared to the respective EGF cells for each line.