Figure 1.

Interferon (IFN) γ production by Mycobacterium tuberculosis–specific CD4⁺ and CD8⁺ T cells in human immunodeficiency virus (HIV)-infected (n = 21) and HIV-uninfected (n = 20) individuals with latent M. tuberculosis infection. A, Representative flow cytometry plots for an HIV-uninfected subject (left) and an HIV-infected subject (right) with latent tuberculosis, demonstrating IFN-γ production by CD4⁺ and CD8⁺ T cells in response to stimulation with ESAT-6/CFP-10 pooled peptides. B and C, Summary data comparing frequencies of M. tuberculosis–specific CD4⁺IFN-γ⁺ (B) and CD8⁺IFN-γ⁺ (C) T cells in HIV-uninfected versus HIV-infected individuals with latent tuberculosis. Horizontal lines indicate median frequency of IFN-γ⁺–producing T-cell subsets. No significant difference was noted between the 2 groups. Abbreviation: NS, nonstimulated cells.