Table 5.
Summary of significant associations between lung-predominant sarcoidosis and HLA DRB1 and DQB1 alleles in UK, Dutch and Japanese populations
| Alleles | Lung-predominant sarcoidosis (%) | Control (%) | P | OR | 95% CI | |
|---|---|---|---|---|---|---|
| UK | N = 233 | N = 354 | ||||
| Risk | DRB1*12 | 9.9 | 2.5 | <0.0001 | 4.2 | 1.91–9.25 |
| DRB1*1401/2 | 14.6 | 5.9 | 0.001 | 2.7 | 1.53–4.80 | |
| DQB1*0503/4 | 14.2 | 5.6 | 0.001 | 2.8 | 1.54–4.93 | |
| DRB1*10 | 2.1 | 0.0 | 0.01 | N/A | ||
| Protection | DRB1*0401–DQB1*0301 | 5.6 | 17.5 | <0.0001 | 0.3 | 0.15–0.52 |
| DRB1*01 | 12.4 | 21.8 | 0.006 | 0.5 | 0.32–0.81 | |
| DQB1*0301 | 32.2 | 43.2 | 0.009 | 0.6 | 0.44–0.88 | |
| DRB1*04 | 23.2 | 36.7 | 0.001 | 0.5 | 0.36–0.76 | |
| Dutch | N = 78 | N = 218 | ||||
| Risk | DQB1*0503/4 | 20.5 | 5.5 | <0.0001 | 4.4 | 1.99–9.86 |
| DRB1*1401/2 | 19.2 | 6.9 | 0.004 | 3.2 | 1.49–6.96 | |
| Protection | DRB1*01 | 12.8 | 23.9 | 0.058 | 0.5 | 0.23–0.98 |
| Japan | N = 37 | N = 168 | ||||
| Risk | DRB1*12 | 27.0 | 6.5 | 0.001 | 5.3 | 2.05–13.65 |
| DQB1*0301 | 40.5 | 17.3 | 0.004 | 3.3 | 1.52–7.05 | |
| DRB1*1401-2 | 27.0 | 8.9 | 0.006 | 3.8 | 1.54–9.58 | |
| DQB1*0503/4 | 21.6 | 8.3 | 0.04 | 3.0 | 1.17–7.89 | |
| DQB1*0302 | 0.0 | 18.5 | 0.002 | N/A | ||
| Protection | DRB1*01 | 0.0 | 9.5 | 0.08 | N/A | |
| DQB1*0501 | 0.0 | 10.1 | 0.047 | N/A |
The P-values in this table are uncorrected. P < 0.001 is considered significant after correction for the number of alleles (n = 28) and is shown in bold.