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. 2014 Nov 28;24(6):1764–1773. doi: 10.1093/hmg/ddu594

Figure 4.

Figure 4.

Sox9 haploinsufficiency initiated in prehypertrophic chondrocytes simultaneously with mutant activated FGFR3 partially restores endochondral bone growth. (A) Representative examples of Alcian blue- and Alizarin red-stained hindlimbs and forelimbs from COL10CRE, COL10CRE;TDII and COL10CRE;TDII;SOX9f/+ littermates at E18.5. Green brackets demarcate the length of the long bones. (B) The mean percentage of the length of the hindlimb and forelimb long bones and third digit of COL10CRE;TDII and COL10CRE;TDII;SOX9f/+ relative to their littermate controls is shown. Standard deviations are indicated (N = 6 for COL10CRE;TDII and N = 5 COL10CRE;TDII;SOX9f/+).