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. 2014 Oct 6;70(2):470–478. doi: 10.1093/jac/dku374

Figure 1.

Figure 1.

In vitro interaction between farnesol (0.586–300 μM) and fluconazole (8–512 mg/L) against C. albicans biofilms based on the Bliss independence no interaction model. The x-axis and y-axis represent the concentrations of farnesol and fluconazole and the z-axis represents the % ΔE (see the text). The zero plane (ΔE = 0) represents indifferent interactions whereas volumes above (ΔE > 0) represent statistically significant synergistic interactions. The magnitude of the synergistic interactions is directly related to positive ΔE value. The different tones in the three-dimensional plots represent different percentile bands of synergy. The % ΔE ± SEM was 38.0% ± 7.1% for the farnesol/fluconazole combination (synergistic interaction). The combination of farnesol and fluconazole against C. albicans biofilms resulted in a 1217.1% sum of statistically significant interactions (∑SYN).