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. 2014 Oct 6;70(2):470–478. doi: 10.1093/jac/dku374

Figure 5.

Figure 5.

Effect of farnesol combination treatment on C. albicans biofilms. (a) Untreated biofilm. (b) Biofilm exposed to fluconazole at 64 mg/L. (c) Biofilm exposed to combination treatment of farnesol at 37.5 μM plus fluconazole at 64 mg/L. (d) Biofilm exposed to amphotericin B at 0.5 mg/L. (e) Biofilm exposed to combination treatment with farnesol at 37.5 μM plus amphotericin B at 0.5 mg/L. (f) Biofilm exposed to micafungin at 2 mg/L. (g) Biofilm exposed to combination treatment with farnesol at 150 μM plus micafungin at 2 mg/L. Concanavalin A-Alexa Fluor 647 conjugate (green stain highlighting the Candida cell walls) and FUN-1 (yellow-orange stain highlighting non-viable cells) were used to directly visualize the effects of antifungal agents on biofilms. Images are single optical sections. Farn, farnesol; FLC, fluconazole; AMB, amphotericin B; MFG, micafungin. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC.