Table 2.
In vitro interactions by Bliss independence analysis of farnesol in combination with antifungal agents against C. albicans biofilms
| Antifungal combination | Number of experimentsa | Type of interaction | Mean % ΔE value (range) | Mean % SEM (range) | ∑SYN% (n) |
|---|---|---|---|---|---|
| Farnesol and fluconazole | 3 | synergistic | 38.03 (23.10–48.86) | 7.11 (3.19–9.8) | 1217.1 (32) |
| Farnesol and amphotericin B | 3 | synergistic | 16.23 (6.88–30.86) | 2.56 (1.27–4.16) | 438.2 (27) |
| Farnesol and micafungin | 5 | synergistic | 43.72 (38.74–51.96) | 8.21 (6.28–10.33) | 480.9 (11) |
ΔE, the experimental observed percentage of growth subtracted from the calculated percentage of growth according to the Bliss independence model theory (see the text).
∑SYN, the sum of percentages of all synergistic interactions.
n, the number of separate combinations with statistically significant synergistic interactions.
aPerformed in triplicate.