Table 1. Baseline characteristics of the effectiveness analysis population (n=21 341).
|
Age at baseline (years)a |
P for trendb | ||||
|---|---|---|---|---|---|
|
⩾75 |
|||||
| <65 (n=9817) | 65–74 (n=6792) | (n=4732) | Subgroup ⩾80 (n=2095) | ||
| Age (years) | 54.4±7.8 | 69.5±2.9 | 79.8±4.1 | 83.5±3.4 | <0.0001 |
| Women | 4333 (44.1) | 3595 (52.9) | 2856 (60.4) | 1352 (64.5) | <0.0001 |
| Body mass index (kg m−2) | 24.99±3.93 | 24.02±3.33 | 23.22±3.37 | 22.77±3.40 | <0.0001 |
| Duration of hypertension (years)c | 3.92±4.11 | 5.44±4.49 | 6.72±4.32 | 7.03±4.22 | <0.0001 |
| History | |||||
| Cerebrovascular disease | 384 (3.9) | 509 (7.5) | 523 (11.1) | 250 (11.9) | <0.0001 |
| Cardiovascular disease | 209 (2.1) | 354 (5.2) | 403 (8.5) | 198 (9.5) | <0.0001 |
| Complications | |||||
| Dyslipidemia | 4195 (42.7) | 3228 (47.5) | 2061 (43.6) | 824 (39.3) | 0.0284 |
| Diabetes mellitus | 1761 (17.9) | 1635 (24.1) | 968 (20.5) | 365 (17.4) | <0.0001 |
| Chronic kidney disease | 1117 (11.4) | 1476 (21.7) | 1691 (35.7) | 885 (42.2) | <0.0001 |
| Regular alcohol drinkers | 2113 (21.5) | 956 (14.1) | 370 (7.8) | 131 (6.3) | <0.0001 |
| Current smokers | 1808 (18.4) | 601 (8.8) | 209 (4.4) | 59 (2.8) | <0.0001 |
| Patients who had received antihypertensive treatment | 4141 (42.2) | 3701 (54.5) | 2890 (61.1) | 1315 (62.8) | <0.0001 |
| Calcium channel blockers | 2910 (29.6) | 2647 (39.0) | 2133 (45.1) | 972 (46.4) | <0.0001 |
| Angiotensin II receptor blockers | 1697 (17.3) | 1604 (23.6) | 1234 (26.1) | 534 (25.5) | <0.0001 |
| β-Blockers | 492 (5.0) | 474 (7.0) | 370 (7.8) | 175 (8.4) | <0.0001 |
| Diuretics | 408 (4.2) | 420 (6.2) | 402 (8.5) | 203 (9.7) | <0.0001 |
| Angiotensin-converting enzyme inhibitors | 274 (2.8) | 288 (4.2) | 218 (4.6) | 103 (4.9) | <0.0001 |
| α-Blockers | 143 (1.5) | 152 (2.2) | 159 (3.4) | 65 (3.1) | <0.0001 |
| No. of previous antihypertensive drugs | 0.6±0.8 | 0.8±0.9 | 1.0±1.0 | 1.0±1.0 | <0.0001 |
a
Mean±s.d. or n (%).
b
Data were compared between patients aged <65, 65–74 and ⩾75 years. The Cochran–Armitage test was used for categorical variables and the Jonckheere–Terpstra test for continuous variables.
c
Recorded as 10 years for patients who had hypertension for ⩾10 years.