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. 2015 Mar 6;47(3):e144. doi: 10.1038/emm.2014.110

Table 1. SNPs in the OAS family.

Gene SNP Associated clinical phenotype Location Nucleotide change SNP effect
Oas1 rs10774671 WNV Intron G/A Different splicing
    T1D      
  rs12307655 HPV Intron C/T  
  rs2660 SARS Exon6 A/G Arg/Gly substitution
    HCV      
           
Oas2 rs2010604 SVR 3′ UTR G/C  
  rs1293762 SVR Intron T/G  
    TBEV      
  rs15895 TBEV 3′ UTR/exon11 A/G Early stop codon
  rs1732778 TBEV 3′ UTR G/A  
  rs718802 HPV 3′ UTR C/A  
           
Oas3 rs2285932 TBEV Exon6 T/C Synonymous
  rs2072136 HBV Exon2 C/G Synonymous
    TBEV      
  rs12302655 HPV 5′ UTR G/A  
           
Oasl rs1169279 SVR 3′ UTR A/G  
  rs3213545 SVR Exon2 C/T Synonymous
    WNV      
    MCRT      
  rs2859398 SVR Promoter C/T  

Abbreviations: HCV, hepatitis C virus;54 HPV, human papillomavirus;55 MCRT, multiple cardiovascular-related traits; OAS, oligoadenylate synthase; SARS, severe acute respiratory syndrome;56 SNP, single-nucleotide polymorphism; SVR, sustained virologic response; TBEV, tick-borne encephalitis virus;58 T1D, type I diabetes;57 UTR, untranslated region; WNV, West Nile Virus.