Table 2. Duration of URTI symptoms, absence and paediatric physician visits.
|
PP analysis |
ITT analysis |
|||
|---|---|---|---|---|
| Placebo (N=29) | Active (N=28) | Placebo (N=33) | Active (N=33) | |
| URTI symptoms | ||||
| Mean (s.d.), days | 43.1 (35.4) | 22.1 (21.0) | 41.5 (34.5) | 23.5 (21.8) |
| Mean difference (95% CI) | −21.0 (−35.9,−6.0) | −17.9 (−31.6,−4.2) | ||
| P-value | 0.006 | 0.011 | ||
| Individual URTI symptoms | ||||
| Sneezing | ||||
| Mean (s.d.), days | 9.6 (14.8) | 2.3 (4.0) | 9.0 (14.1) | 3.8 (8.6) |
| Mean difference (95% CI) | −7.4 (−12.9, −1.8) | −5.1 (−10.7, 0.4) | ||
| P-value | 0.010 | 0.069 | ||
| Cough | ||||
| Mean (s.d.), days | 23.5 (20.3) | 11.9 (10.1) | 22.3 (19.8) | 14.3 (14.4) |
| Mean difference (95% CI) | −11.6 (−19.8, −3.4) | −7.9 (−16.2, 0.3) | ||
| P-value | 0.006 | 0.058 | ||
| Runny nose | ||||
| Mean (s.d.), days | 21.4 (25.5) | 11.5 (15.6) | 19.8 (24.6) | 12.3 (15.8) |
| Mean difference (95% CI) | −10.0 (−20.8, 0.9) | −7.4 (−17.2, 2.4) | ||
| P-value | 0.072 | 0.138 | ||
| Blocked nose | ||||
| Mean (s.d.), days | 9.8 (23.8) | 4.9 (7.8) | 10.4 (23.0) | 5.4 (8.4) |
| Mean difference (95% CI) | −5.0 (−14.1, 4.1) | −5.0 (−13.2, 3.2) | ||
| P-value | 0.285 | 0.230 | ||
| Sore throat | ||||
| Mean (s.d.), days | 2.8 (4.2) | 1.9 (2.7) | 3.2 (4.3) | 1.8 (2.6) |
| Mean difference (95% CI) | −0.9 (−2.7, 0.9) | −1.4 (−3.1, 0.3) | ||
| P-value | 0.332 | 0.010 | ||
| Absence, physician visits | ||||
| Absence from preschool due to URTI | ||||
| Mean (s.d.), days | 14.2 (18.4) | 7.5 (8.0) | 13.9 (17.7) | 7.7 (8.6) |
| Mean difference (95% CI) | −6.7 (−14.0, 0.5) | −6.1 (−12.8, 0.5) | ||
| P-value | 0.070 | 0.069 | ||
| Number of physician visit due to URTI | ||||
| Mean (s.d.) | 2.9 (3.1) | 1.6 (2.2) | 2.8 (3.0) | 1.8 (2.4) |
| Mean difference (95% CI) | −1.2 (−2.6, 0.2) | −0.9 (−2.2, 0.4) | ||
| P-value | 0.082 | 0.164 | ||
Abbreviations: CI, confidence interval; ITT, intention to treat; PP, per protocol; URTI, upper respiratory tract infection.