Table 3. Incidence rate of URTI symptoms and absence.

	PP analysis		ITT analysis
	Incidence rate ratio (95% CI)	P-value	Incidence rate ratio (95% CI)	P-value
URTI symptoms	0.67 (0.52, 0.86)	0.002	0.68 (0.54, 0.86)	0.002
Individual URTI symptoms
Sneezing	0.29 (0.19, 0.47)	<0.001	0.35 (0.23, 0.53)	<0.001
Cough	0.55 (0.40, 0.76)	<0.001	0.60 (0.45, 0.81)	0.001
Runny nose	0.64 (0.47, 0.87)	0.005	0.66 (0.50, 0.89)	0.005
Blocked nose	1.15 (0.69, 1.91)	0.600	1.01 (0.64, 1.59)	0.966
Sore throat	0.70 (0.39, 1.26)	0.235	0.63 (0.37, 1.08)	0.095
Absence
Absence from preschool	0.70 (0.55, 0.91)	0.007	0.68 (0.54, 0.87)	0.002

Abbreviations: CI, confidence interval; ITT, intention to treat; PP, per protocol; URTI, upper respiratory tract infection.