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Surface engineered Fabs bind to VCIII glycine riboswitch. The binding affinities of VCIII with Fab18, Fab18SMA, Fab20 and Fab20SMA were 274 ± 20, 249 ± 9, 118 ± 5 and 182 ± 17 nM, respectively. Fab18 and Fab20 were selected from the YSGRX library and the CDR sequences are SSSSPY (L3), SIYYSSI (H1), SIYPSSGSTY (H2), YRSYRRRSRSGI (H3) for Fab18 and HYTTPP (L3), SISSSSI (H1), YISPYSGYTS (H2), YGRYGRYYYRRGGF (H3) for Fab20.
