Table 3.

Pre (T1), Mid (T2), and Post (T3) neuroimaging results at rest per MR technique (mean ± SEM)

	Control (CN)			Cognitive training (CT)			P-value
	T1	T2	T3	T1	T2	T3	Linear	Quadratic
WB aCBF	47.2 ± 1.1	44.3 ± 2.0	46.8 ± 2.0	47.0 ± 2.4	50.7 ± 2.3	50.7 ± 2.4	0.04	0.002
WB fcMRI	0.12 ± 0.02	0.10 ± 0.02	0.11 ± 0.02	0.11 ± 0.02	0.10 ± 0.02	0.11 ± 0.02	0.73	0.76
WB FA	0.425 ± 0.002	0.424 ± 0.002	0.424 ± 0.002	0.425 ± 0.002	0.424 ± 0.002	0.426 ± 0.002	0.37	0.75
fcMRI (DMN)	6.8 ± 0.4	7.1 ± 0.4	6.6 ± 0.4	6.3 ± 0.4	6.7 ± 0.4	7.1 ± 0.4	0.04	0.26
aCBF (DMN)	55.6 ± 2.8	49.9 ± 2.7	53.2 ± 2.7	55.3 ± 3.1	59.4 ± 3.0	62.0 ± 3.0	0.01	0.06
fcMRI (CEN)	4.0 ± 0.4	3.8 ± 0.4	4.1 ± 0.4	3.6 ± 0.4	4.7 ± 0.4	4.3 ± 0.4	0.23	0.03
aCBF (CEN)	47.0 ± 2.5	41.2 ± 1.8	44.2 ± 2.0	48.2 ± 2.8	54.2 ± 2.0	52.5 ± 2.2	0.01	0.001
DTI MT (L. UF)	0.502 ± 0.006	0.498 ± 0.006	0.495 ± 0.006	0.488 ± 0.007	0.495 ± 0.007	0.503 ± 0.006	0.003	0.45
DTI MT (R. UF)	0.470 ± 0.005	0.468 ± 0.005	0.476 ± 0.005	0.481 ± 0.006	0.481 ± 0.006	0.482 ± 0.006	0.53	0.42
DTI AT (L. UF)	0.498 ± 0.007	0.493 ± 0.007	0.493 ± 0.007	0.493 ± 0.008	0.494 ± 0.007	0.504 ± 0.007	0.02	0.41

Notes: WB, whole brain; aCBF, absolute cerebral blood flow in mL/min/100 g; fcMRI, functional connectivity MRI in z-score; DMN, default mode network; CEN, central executive network; DTI, diffusion tensor imaging; UF, uncinate fasciculus; MT, manual tractography of UF; AT, automatic tractography of UF; and L/R, left/right.

Linear and quadratic refer to orthogonal polynomial contrasts of mean group differences over the 3 training sessions.