Table 1.
Biochemical and hormonal findings in patients with primary adrenal insufficiency (PAI) and healthy controls
| Unit | PAI patients (n = 63) | Healthy controls (n = 63) | p value | ||
|---|---|---|---|---|---|
| Mean ± SD | Range | Mean ± SD | Range | ||
| Fasting glucose (mmol/l) | 4.7 ± 0.7 | 3.4–6.2 | 4.8 ± 0.7 | 3.2–6.8 | 0.257 |
| Fasting insulin (mU/l) | 8.8 ± 6.6 | 2.6–32.6 | NA | ||
| HOMA-IR | 1.9 ± 1.7 | 0.4–7.6 | NA | ||
| Total cholesterol (mmol/l) | 5.4 ± 1.3 | 2.8–9.0 | 5.2 ± 1.1 | 2.9–8.1 | 0.601 |
| HDL (mmol/l) | 1.7 ± 0.5 | 0.9–3.1 | 1.6 ± 0.5 | 0.9–2.8 | 0.457 |
| LDL (mmol/l) | 3.0 ± 1.1 | 0.9–6.0 | 2.9 ± 1.0 | 1.1–5.3 | 0.582 |
| Triglycerides (mmol/l) | 1.4 ± 0.7 | 0.4–3.9 | NA | ||
| ACTH (pg/ml) | 434 ± 444 | 18–1569 | NA | ||
| Cortisol (nmol/l) | 36.5 ± 42.5 | 0–163.6 | 417.8 ± 169.1 | 155.3–721.5 | <0.001 |
| DHEA-S (μg/dl) | 64.4 ± 97.9 | 0.1–209.6 | NA | ||
| UFC (nmol/24 h/m2) | 197 ± 101 | 43–403 | NA | ||
Statistically significant value is given in bold
NA non-assessed, UFC urinary free cortisol