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. Author manuscript; available in PMC: 2015 Mar 6.
Published in final edited form as: Synapse. 2008 May;62(5):325–336. doi: 10.1002/syn.20497

Fig. 6.

Fig. 6

DAT immunoreactivity in the striatum 5 days after injections of saline (0.9% NaCl, 1 ml/kg) or METH (7.5 mg/kg, i.p.; q 2 h × 4). (A) METH alone depleted DAT levels relative to saline-treated rats (#P < 0.05). Previously stressed rats showed greater decreases in DAT immunoreactivity in response to METH compared with no-stressed controls (*P < 0.05). (B) Metyrapone attenuated the enhanced DAT depletions in Stress/METH group relative to VehStress/METH rats (¥P < 0.05). Representative Western blots are shown below the graphs, representing the 78-kDa DAT band. Values are expressed as means ± SEM percent of saline relative optical densities; n = 4–8 per treatment group. NSS, NoStress/Saline; SS, Stress/Saline; NSM, NoStress/METH; SM, Stress/METH; Veh/SM, Veh/StressMETH; Met/SM, Met/StressMETH.