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Elevated plasma adenosine induces erythrocyte SphK1 activity increase in vivo. (A) Schematic representation of mouse treatment strategy. (B) Plasma adenosine and (C) erythrocyte SphK1 activity in Ada+/−, Ada−/− with PEG-ADA treatment, Ada−/− without PEG-ADA treatment, and Ada−/− rescue. Values shown represent the mean ± SEM (n = 6 for each group). *P < .05 Ada−/− vs Ada−/−+ PEGADA;**P < .05 Ada−/− vs Ada−/− rescue.
