Table 3.
In vivo vs In vitro anti-Inflammatory effects (Burstein et al., unpublished)
| Test Molecule | PGJ2 Activity* (% Control) | Activity in Ear Edema Assay** |
|---|---|---|
| Palmitoyl glycine (PALgly) | 100 | 0 |
| Oleoyl 1,1-dimethyl glycine | 118 | + |
| γ-Linolenoyl glycine (LINgly) | 203 | ++ |
| Arachidonoyl glycine (NAgly) | 213 | ++ |
| Arachidonoyl l-alanine | 212 | ++ |
| Arachidonoyl 1,1-dimethyl glycine | 220 | +++ |
*
Stimulation of PGJ2 synthesis by 10 μM compound in mouse macrophage RAW cells.
**
Relative potency in inhibiting phorbol ester-induced ear swelling in mice. Compounds applied topically in safflower oil at 1 mg/ml.