Table 4. Genotype distribution of genotypes of the COMT Val158Met polymorphism after stratification of the MTHFR C677T genotypes.
| Gene polymorphisms and Group | (n) | BP-II (%) | Controls (%) | χ2 | P | OR | 95% CI |
|---|---|---|---|---|---|---|---|
| MTHFR C677T C/C Genotype | |||||||
| COMT Val158Met Genotypes | (n = 287) | (n = 215) | |||||
| Val/Val | 282 | 163 (56.8) | 119 (55.3) | 0.104 | 0.785 | 1.026 | 0.877–1.200 |
| Val/Met + Met/Met | 220 | 124 (43.2) | 96 (44.7) | 1 | |||
| MTHFR C677T C/T + T/T Genotype | |||||||
| COMT Val158Met Genotypes | (n = 244) | (n = 232) | |||||
| Val/Val | 241 | 109 (44.7) | 132 (56.9) | 7.11 | 0.008** | 0.785 | 0.656–0.939 |
| Val/Met + Met/Met | 235 | 135 (55.3) | 100 (43.1) | 1 |
OR = odds ratio; CI = confidence interval.
**P < 0.01.