Table 5. Multivariate logistic regression analysis of COMT and MTHFR genes and their interaction for the risk of bipolar-II disorder.
| Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|
| Variable | Odds Ratio | 95% CI | P | Odds Ratio | 95% CI | P |
| Age | 0.96 | 0.95–0.98 | <0.001*** | |||
| Gender (Male vs. Female) | 0.30 | 0.23–0.40 | <0.001*** | |||
| COMT Val/Val genotype | 1.05 | 0.74–1.51 | 0.747 | 1.09 | 0.75–1.58 | 0.764 |
| MTHFR C/T + T/T genotype | 1.06 | 0.72–1.52 | 0.816 | 1.06 | 0.72–1.57 | 0.669 |
| COMT Val/Val × MTHFR C/T + T/T genotype | 0.58 | 0.35–0.96 | 0.034* | 0.57 | 0.33–0.97 | 0.039* |
OR = odds ratio; 95% CI = 95% confidence interval. Covarying for age and gender; reference groups are COMT Val/Met + Met/Met, MTHFR C/C genotypes, and healthy control groups.
*P < 0.05, ***P < 0.001.