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. Author manuscript; available in PMC: 2015 Mar 6.
Published in final edited form as: J Cardiovasc Pharmacol. 1987 Apr;9(4):396–400. doi: 10.1097/00005344-198704000-00003

FIG. 2.

FIG. 2

Effect of increasing doses of N-5′-ethylcarboxamidoadenosine (NECA) on blood pressure and heart rate in anesthetized rats in the presence of increasing doses of two novel derivatives (XAC and XCC) (compounds 2 and 3 in Fig. 1). Upper graph: effect of the two compounds on the blood pressure response to NECA. The solid line without symbols shows the effect of NECA. The solid lines with symbols show the effect of XAC and the hatched lines the effect of XCC. Lower graph: corresponding effects on heart rate. Insert: Schild plots for the compounds and the estimated potentials (in mg/kg), calculated from the pA2 values. Solid lines represent effects on blood pressure, hatched lines effects on heart rate. Dots show the effect of XAC, open circles the effect of XCC. The initial blood pressure/heart rate and SD and number of experiments were as follows: control, 138 ± 28/411 ± 36 (n = 6); XAC (1–10 μg/kg), 136 ± 21/458 ± 42 (n = 10); and XCC 113 ± 23/410 ± 58 (n = 10).