Table 1.
Studies using tDCS for the treatment of auditory hallucinations (AH).
| Reference | Design | Patients | Position of electrodes | Current strength | Duration | Effects |
|---|---|---|---|---|---|---|
| Andrade (2013) | Case study | One subject with schizophrenia and clozapine resistant AH. | The cathode over the left temporoparietal cortex (TPC) and the anode over the left dorsolateral prefrontal cortex (DLPFC). | First 1 mA, later 3 mA | First 20 min (daily sessions for 2 consecutive months), later 30 min (twice daily sessions for 3 consecutive years). | A reduction of 90% in AH severity was reported after the first 2 months. After increasing treatment to twice daily and a current intensity of 3 mA, AH severity further improved. When electrode positioning was changed or treatment frequency was reduced to once per 2 days, the ameliorating effects disappeared. |
| Bose et al. (2014) | Open label study, without a placebo condition | 21 subjects with schizophrenia and medication resistant AH. | The cathode over the left TPC and the anode over the left DLPFC. | 2 mA | 20 min (twice daily sessions on 5 consecutive days). | Improvement of 32% in AH severity. |
| Brunelin et al. (2012) | Randomized, placebo controlled, double-blind trial | 30 subjects with schizophrenia and medication resistant AH. | The cathode over the left TPC and the anode over the left DLPFC. | 2 mA | 20 min (twice daily sessions on 5 consecutive days). | Improvement of 31% in AH severity which lasted for 3 months. |
| Fitzgerald et al. (2014) | Randomized, placebo controlled, double-blind trial | 24 subjects with schizophrenia or schizoaffective disorder and medication resistant AH. | Unilateral and bilateral tDCS with the cathode over the (left) TPC and the anode over the (left) DLPFC. | 2 mA | 20 min (daily sessions on 15 days in 3 consecutive weeks) | AH did not respond to either treatment method, and no difference was found between the active and placebo treatment group. |
| Homan et al. (2011) | Case study | One subject with schizophrenia and medication resistant AH. | The cathode over the left TPC and the anode over the right supraorbital area. | 1 mA | 15 min (daily sessions on 10 consecutive days) | Amelioration of AH was reported, which was still present 6 weeks after treatment. |
| Mondino et al. (2014) | Randomized, placebo controlled, double-blind trial | 28 subjects with schizophrenia and medication resistant AH. | The cathode over the left TPC and the anode over the left DLPFC. | 2 mA | 20 min (twice daily sessions on 5 consecutive days). | Improvement of 46% in AH severity in the active treatment group, with no such effect in the placebo group. |
| Nawani et al. (2014) | Case study | One subject with schizophrenia and medication resistant AH. | The cathode over the left TPC and the anode over the left DLPFC. | 2 mA | 20 min (twice daily sessions on 5 consecutive days). | Improvement of AH. |
| Rakesh et al. (2013) | Case study | One subject with schizophrenia and medication resistant AH. | The cathode over the left TPC and the anode over the left DLPFC. | 2 mA | 20 min (twice daily sessions on 5 consecutive days). | Complete cessation of AH. |
| Shiozawa et al. (2013) | Case study | One subject with schizophrenia and medication resistant AH. | The cathode over the left TPC and the anode over the left DLPFC. | 2 mA | 20 min (twice daily sessions on 5 consecutive days). | Improvement of AH, which was sustained after a 2-month follow-up. |
| Shivakumar et al. (2013) | Case study | One subject with schizophrenia and medication resistant AH. | The cathode over the left TPC and the anode over the left DLPFC. | 2 mA | 20 min (twice daily sessions on 5 consecutive days). | Complete cessation of AH, which was sustained after a 4-week follow-up. |