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. 2015 Feb 26;6:6241. doi: 10.1038/ncomms7241

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M2-type Mφs are recruited to the aortic adventitia after blood-pressure elevation and secrete C1q. Mφ-derived C1q and VSMC-derived C1r/s might compose the C1 complex, which plays a pivotal role in initiating hypertensive arterial remodelling through activating β-catenin signalling in VSMCs and inducing proliferation of VSMCs.