Table 2.
Clinical and Physiologic Characteristics of Both Cohorts
| P-IELCAP (n = 572) | PLuSS (n = 1,553) | P Value | |
|---|---|---|---|
| Age, yr* | 61 ± 9 | 61 ± 7 | 0.66 |
| Sex (female/male), % | 17/83 | 43/56 | <0.001 |
| BMI, kg/m2* | 27 ± 4 | 27 ± 5 | 0.05 |
| Pack-years† | 43 (30–60) | 53 (39–70) | <0.001 |
| Active smoker, % | 34 | 33 | 0.47 |
| FEV1%† | 79 (66–91) | 71 (58–83) | <0.001 |
| FEV1/FVC† | 62 (56–66) | 62 (55–66) | 0.97 |
| Years of former smoker† | 7 (3–15) | 4 (1–8) | <0.001 |
| Family history LC (yes), % | 17 | 17 | 0.89 |
| GOLD I-II vs. III-IV, % | 93 vs. 7 | 85 vs. 15 | <0.001 |
| LDCT emphysema, yes % | 45 | 62 | <0.001 |
| LC diagnosis, n (%) | 33 (6%) | 134 (9%) | 0.03 |
| LC incidence density | 2.29/100 | 1.05/100 | <0.001 |
| LC annual detection rate | 5.34 | 0.9 | |
| Follow-up, mo† | 13 (1–48) | 108 (95–118) | <0.001 |
Definition of abbreviations: BMI = body mass index; GOLD = Global Initiative for Obstructive Lung Disease; LC = lung cancer; LDCT = low-dose computed tomography; P-IELCAP = Pamplona International Early Lung Cancer Detection Program; PLuSS = Pittsburgh Lung Screening Study.
*
Mean ± SD.
†
Median (25th–75th percentiles).