Table 3.
Univariable and Multivariable Cox Analysis Exploring the Independent Association of the Studied Variables with LC Diagnosis in the PLuSS Cohort
| P Value | HR | 95% CI | |
|---|---|---|---|
| Univariable Cox analysis | |||
| Age >60 vs. <60 | 0.001 | 2.5 | 1.6–3.7 |
| Sex, male vs. female | 0.88 | 0.9 | 0.7–1.4 |
| BMI <25 vs. >25 | 0.026 | 2.1 | 1.1–4.1 |
| Pack-years >60 vs. <60 | 0.001 | 1.9 | 1.3–2.6 |
| Active smoker | 0.37 | 1.2 | 0.8–1.6 |
| Years of former smoker | 0.47 | 1.6 | 0.5–5.0 |
| Family history LC, yes vs. no | 0.29 | 1.2 | 0.8–1.8 |
| GOLD I-II vs. III-IV | 0.04 | 1.4 | 1.04–1.6 |
| Emphysema, yes vs. no | 0.001 | 3.5 | 2.3–5.2 |
| Multivariable Cox analysis | |||
| Age >60 vs. <60 | 0.005 | 2.3 | 1.5–3.5 |
| BMI <25 vs. >25 | 0.15 | 1.2 | 0.9–1.8 |
| Pack-years >60 vs. <60 | 0.001 | 1.5 | 1.1–2.2 |
| Emphysema, yes vs. no | 0.001 | 2.7 | 1.7–4.3 |
Definition of abbreviations: BMI = body mass index; CI = confidence interval; GOLD = Global initiative for Obstructive Lung Disease; HR = hazard ratio; LC = lung cancer; PLuSS = Pittsburgh Lung Screening Study.