Table 2.
Cancer Tissue* |
TSC1 Loss of Heterozygosity |
TSC1 Mutation |
TSC2 Loss of Heterozygosity |
TSC2 Mutation |
||||
---|---|---|---|---|---|---|---|---|
Samples (n) | Loss of Heterozygosity [n (%)] | Samples (n) | Mutated Samples [n (%)] | Samples (n) | Loss of Heterozygosity [n (%)] | Samples (n) | Mutated Samples (%) | |
Lung | 476 | 139 (29.2) | 1,184 | 19 (1.6) | 476 | 92 (19.3) | 1,183 | 20 (1.7) |
Breast | 852 | 138 (16.2) | 1,174 | 8 (0.7) | 852 | 56 (6.6) | 1,174 | 6 (0.5) |
CNS | 638 | 45 (7.1) | 1,231 | 4 (0.3) | 638 | 49 (7.7) | 1,232 | 14 (1.1) |
Endometrium | 246 | 35 (14.2) | 271 | 14 (5.2) | 246 | 19 (7.7) | 271 | 17 (6.3) |
Kidney | 435 | 87 (20.0) | 911 | 11 (1.2) | 435 | 29 (6.7) | 847 | 20 (2.4) |
Large intestine | 540 | 36 (6.7) | 723 | 30 (4.1) | 540 | 20 (3.7) | 723 | 31 (4.3) |
Ovary | 462 | 159 (34.4) | 577 | 5 (0.9) | 462 | 159 (34.4) | 610 | 5 (0.8) |
Definition of abbreviation: CNS = central nervous system.
Data are collected from catalog of somatic mutations in cancer database (14).