Table 1.
Clinical and Demographic Data for the Derivation Cohort
| Subclass A | Subclass B | |
|---|---|---|
| n | 57 | 111 |
| Median age (IQR), yr | 1.4 (0.2–2.9) | 3.0 (1.5–7.3)* |
| Males, n (%) | 36 (63) | 64 (58) |
| 28-d mortality, n (%) | 12 (21) | 11 (10)† |
| Complicated course, n (%) | 24 (42) | 26 (23)† |
| Median PRISM score (IQR) | 16 (12–23) | 13 (9–20)* |
| Median WBC count ×103/mm3 (IQR) | 10.0 (3.8–16.9) | 14.6 (7.7–19.9)* |
| Median neutrophil count ×103/mm3 (IQR) | 6.1 (2.4–11.4) | 10.9 (4.5–16.8)* |
| Median lymphocyte count ×103/mm3 (IQR) | 1.8 (0.9–3.5) | 1.5 (0.7–2.5)* |
| Median monocyte count ×103/mm3 (IQR) | 0.6 (0.1–1.4) | 0.6 (0.2–1.3) |
| No. with gram-negative bacteria (%) | 11 (19) | 26 (23) |
| No. with gram-positive bacteria (%) | 16 (28) | 28 (25) |
| No. with other pathogen isolated (%) | 6 (11) | 5 (5) |
| No. with no pathogen identified (%) | 24 (42) | 52 (47) |
| No. with comorbidity (%) | 11 (19) | 46 (41)† |
| No. with malignancy (%) | 1 (2) | 8 (7) |
| No. with immune suppression (%) | 3 (5) | 11 (10) |
| No. with bone marrow transplantation (%) | 1 (2) | 5 (5) |
Definition of abbreviations: IQR = interquartile range; PRISM = Pediatric Risk of Mortality; WBC = white blood cell.
*
P < 0.05 versus subclass A, rank sum test.
†
P < 0.05 versus subclass A, chi-square.