Figure 3.

(A) Schematic of the orthotopic lung transplant with prolonged cold ischemia (PCI) model. (B) Extravascular lung water (ELW) and (C) extravascular plasma equivalents (EVPE) (n ≥ 8 in each group), (D) bronchoalveolar lavage fluid protein concentration (n = 7 in each group), and (E) bronchoalveolar lavage fluid neutrophil count (n ≥ 6 in each group) are all increased in lungs transplanted after PCI as compared with lungs transplanted immediately after harvest (control group). (F) The arterial blood partial pressure of oxygen (Po₂) is lower in mice that received lung grafts subjected to PCI (n = 4 in each group). *P < 0.05, **P < 0.01.