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Immunohistochemical detection of neoplastic mast cells in the patient’s bone marrow (BM). BM sections were examined by indirect immunohistochemistry using an antibody against KIT (upper panel) and against tryptase (lower panel). Original magnification x 60. Note the presence of multifocal, perivascular accumulations of mast cells which is a pathognomonic feature and major criterion of systemic mastocytosis (SM).
