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. Author manuscript; available in PMC: 2015 Mar 6.
Published in final edited form as: Ann Biomed Eng. 2011 Dec 6;40(6):1356–1366. doi: 10.1007/s10439-011-0479-y

Figure 3.

Figure 3

Membrane reorganization is induced upon the binding of T cells to antigen presenting cells, forming an immunological synapse. (A) Key elements of antigen presenting cells (i.e. the peptide-major histocompatiability complex (pMHC) and the inter-cellular adhesion molecule (ICAM)) have been incorporated into a SLB and reorganized upon binding to T cell receptors (TCR) and to lymphocyte function-associated antigen 1 (LFA-1), respectively. The (B) presence or (C) absence of the metallic barriers to diffusion results in distinctly different morphology of the resulting immunological synapse as the T cell attempts to concentrate the TCRs within a ring of ICAMs. (Reprinted with permission from Ref. 32.)