Table 2.
Human DC subsets.
| Subsets defined by: | Cell-associated | Soluble protein | IC |
|---|---|---|---|
| CD1c (BDCA1) |
Yes
[2] b/c [88] Low b [89] d [90] c [14] |
Yes
a [8] c [14] c/d [89,93] No d [99] c/d [81] Low [92] d [90] c/d [8] a [81] |
Yes
d [8] Low [92] |
| CD141 (BDCA3) |
Yes
d [90] c [14] b [89] b/c [88] |
Yes
[92] d [90] c [14,89,93,99] No/low d [89,93,99] |
Yes
[92] |
| CBDCs CD141/DNGR1e |
Yes
c/d [82] (long peptide) No d [82] |
||
| pDCs |
Yes
c [14] b [94] b/c [2,88] |
Yes
c [14] c/d [93] Low c/d [14] No d [90] 0/c [8] |
No
c/d [8] |
|
MoDCs
(IL-4/GM-CSF) In vitro |
Yes
Blood [12] b [10,95–98] |
Yes
d [108,111] a/c [8] a [81] No d [8,81] Low c/d [82] (long peptide) |
Yes
c/d [8] [112] |
a
Saponin-based formulation.
b
Cells loaded with virus (and thus intrinsic PRR activity of virus).
c
Matured with TLR-L or CD40L.
d
Not matured.
e
CBDCs, cord blood dendritic cells; DNGR, dendritic cell natural killer lectin group receptor.