Table II.
Subject characteristics of transcriptional intermediary factor-1γ-positive versus -negative patients
| Variable | TIF-1γ positive* (n = 46) |
TIF-1γ negative (n = 76) |
P value† |
|---|---|---|---|
| Gender, n (%) | .034 | ||
| Male | 7 (15) | 26 (34) | |
| Female | 39 (85) | 50 (66) | |
| Age at diagnosis, y, mean (SD) | 49.5 (15.9) | 49.5 (15.9) | .70 |
| Race, n (%) | .36 | ||
| African American | 1 (2) | 5 (7) | |
| Asian | 3 (7) | 12 (16) | |
| Caucasian | 33 (72) | 46 (61) | |
| Latino | 6 (13) | 8 (11) | |
| Pacific Islander | 2 (4) | 5 (7) | |
| Follow-up, y, mean (SD) | 5.0 (3.9) | 6.4 (5.9) | .27 |
| Tobacco [yes or past], n (%) | 6 (14) | 18 (24) | .51 |
| Internal malignancy, n (%) | 10 (22) | 8 (11) | .12 |
| Interstitial lung disease, n (%) | 2 (5) | 18 (27) | .0040 |
| Clinically amyopathic, n (%) | 12 (26) | 16 (21) | .66 |
| CK (maximum), mean (SD) | 342 (593) | 2317 (6177) | .027 |
| Aldolase (maximum), mean (SD) | 8.2 (4.2) | 16 (15.7) | .00010 |
| Review of systems, n (%) | |||
| Raynaud phenomenon | 4 (11) | 23 (35) | .017 |
| Hand swelling | 8 (31) | 19 (37) | .80 |
| Dysphagia | 16 (37) | 30 (44) | .55 |
| Arthralgia/arthritis | 15 (36) | 41 (59) | .031 |
| Pruritus | 40 (89) | 48 (71) | .036 |
CK, Creatine kinase; TIF, transcriptional intermediary factor.
*
Patients with >1 antibody were excluded.
†
Fisher exact test was used to compare categorical variables and Student t test was used to compare continuous variables.