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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: J Neurovirol. 2014 May 28;20(4):398–411. doi: 10.1007/s13365-014-0257-3

Table 6.

Relationship of FMRI Activation to Viral Load Detectability.

Primary Regions Size (Voxels) Max Z-Statistic MNI-Coordinates of Peak (x, y, z)
Detectable >Undetectable
    0-Backa Bilateral cerebellum/occipital 2205 3.75 −8, −84, 8
    2-Backa Bilateral frontal, precuneus, posterior cingulate 8264 0.358 −38, 28, 26
Bilateral orbitofrontal; left temporal/BG 2127 3.92 −16, 4, −24
Bilateral precuneus, posterior cingulate, ACC 7627 3.98 −22, −72, 46
    2-Back > 0-Back b
Bilateral OFC, subgenual cingulate, temporal; left occipital 5741 3.33 −48, 12, −16
Undetectable > Detectable
    0-Back c
Left superior parietal/postcentral 1261 3.35 −36, −24, 64
    2-Backc
Left superior parietal/lateral occipital 1809 4.62 −28, −64, 66
    2-Back > 0-Back c
Diffuse; right ACC, superior frontal; left frontal 6004 4.14 −4, 28, 62
a

Cluster z = 1.699, Family-wise p = 0.001

b

Cluster z = 1.699, Family-wise p = 0.0001

c

Cluster z = 1.699, Family-wise p = 0.005

Note. ACC, Anterior Cingulate Cortex; OFC, Orbitofrontal Cortex; BG, Basal Ganglia. Clusters of significant correlation between neural activation to 0-back, 2-back, and 2-back > 0-back task conditions and current plasma viral load detectability, within each diagnostic group (HIV+, HIV-seronegative, and HIV/HCV coinfected). Positive and negative correlations are listed separately. All regions presented show significant activation for the indicated group and condition. Exact significance levels are presented for each analysis. Coordinates represent peak activation voxel.