Figure 1. PI3KC2β silencing does not alter adherent growth of NB cells.
(A&B) PI3KC2β expression levels in shRNA-expressing NB cell lines. SK-N-AS (A) and IMR-5 (B) NB cells were infected with retrovirus containing the indicated empty vector control (pSR), scrambled shRNA (pSCR), or PI3KC2β shRNAs (βsh2 and βsh5). Stable polyclonal cell lines were generated, lysed, and analyzed by Western blot to assess PI3KC2β levels. Actin is shown as a control for loading. Growth curves of shRNA-expressing SK-N-AS (C) and IMR-5 (D) NB cells from above were determined using Cell TiterGlo (Promega). Each point is the average of three independent wells of cells +/− standard deviation.