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. Author manuscript; available in PMC: 2015 Sep 3.
Published in final edited form as: Nat Commun. 2015 Mar 3;6:6395. doi: 10.1038/ncomms7395

Figure 3. Enhanced cued fear extinction in humans and mice with FAAH C385A.

Figure 3

(a) Extinction, indexed by differential skin conductance response (SCR) [(CS+) – (CS−)], in 18 A-allele carriers and 22 C homozygotes. Trials were binned into early (average of the first 5 trials) and late (average of the following 6 trials). (b) Fear extinction, time spent freezing to cue, was tested in wild type (FAAHC/C; n = 21), heterozygous (FAAHC/A; n = 20) and homozygous knock-in mice (FAAHA/A; n = 20). Extinction trials were binned into early (average of extinction day 1) and late trials (average of extinction day 4). Means ± SEM presented. *P < 0.05, #P < 0.05 heterozygous knock-in mice vs wild-type controls, **P < 0.01 homozygous knock-in mice vs wild-type controls